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1

Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-Ring

Baumann, David O., McGowan, Kevin M., Kedei, Noemi, Peach, Megan L., Blumberg, Peter M., Keck, Gary E.

Journal:

Journal of Organic Chemistry

Year:

2016

Language:

english

File:

PDF, 1.36 MB

english, 2016

2

QSAR Modeling of Imbalanced High-Throughput Screening Data in PubChem

Zakharov, Alexey V., Peach, Megan L., Sitzmann, Markus, Nicklaus, Marc C.

Journal:

Journal of Chemical Information and Modeling

Year:

2014

Language:

english

File:

PDF, 485 KB

english, 2014

3

Concise and Enantioselective Synthesis of Fmoc-Pmp(Bu t ) 2 -OH and Design of Potent Pmp-Containing Grb2-SH2 Domain Antagonists

Li, Peng, Zhang, Manchao, Peach, Megan L., Liu, Hongpeng, Yang, Dajun, Roller, Peter P.

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 99 KB

english, 2003

4

Conformationally Constrained Analogues of Diacylglycerol (DAG). 23 † . Hydrophobic Ligand−Protein Interactions versus Ligand−Lipid Interactions of DAG-Lactones with Protein Kinase C (PK-C)

Tamamura, Hirokazu, Sigano, Dina M., Lewin, Nancy E., Peach, Megan L., Nicklaus, Marc C., Blumberg, Peter M., Marquez, Victor E.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 189 KB

english, 2004

5

Conformationally Constrained Analogues of Diacylglycerol. 29. Cells Sort Diacylglycerol-Lactone Chemical Zip Codes to Produce Diverse and Selective Biological Activities

Duan, Dehui, Sigano, Dina M., Kelley, James A., Lai, Christopher C., Lewin, Nancy E., Kedei, Noemi, Peach, Megan L., Lee, Jeewoo, Abeyweera, Thushara P., Rotenberg, Susan A., Kim, Hee, Kim, Young Ho,

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 3.49 MB

english, 2008

6

Probing the hras -1 Y i-motif with small molecules

Journey, Sara N., Alden, Stephanie L., Hewitt, Will M., Peach, Megan L., Nicklaus, Marc C., Schneekloth Jr, John S.

Journal:

Year:

2018

Language:

english

File:

PDF, 3.36 MB

english, 2018

7

Structure-based design of thioether-bridged cyclic phosphopeptides binding to Grb2-SH2 domain

Peng Li, Megan L Peach, Manchao Zhang, Hongpeng Liu, Dajun Yang, Marc Nicklaus, Peter P Roller

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 271 KB

english, 2003

8

Molecular Modeling, Total Synthesis, and Biological Evaluations of C9-Deoxy Bryostatin 1

Gary E. Keck, Yam B. Poudel, Arnab Rudra, Jeffrey C. Stephens, Noemi Kedei, Nancy E. Lewin, Megan L. Peach, Peter M. Blumberg

Journal:

Angewandte Chemie

Year:

2010

Language:

english

File:

PDF, 521 KB

english, 2010

9

Diagnostic cross-linking of paired cysteine pairs demonstrates homologous structures for two chemoreceptor domains with low sequence identity

Wing-Cheung Lai, Megan L. Peach, Terry P. Lybrand, Gerald L. Hazelbauer

Journal:

Protein Science

Year:

2006

Language:

english

File:

PDF, 575 KB

english, 2006

10

Structural basis for a non-phosphorus-containing cyclic peptide binding to Grb2-SH2 domain with high affinity

Peng Li, Manchao Zhang, Megan L Peach, Xiaodong Zhang, Hongpeng Liu, Marc Nicklaus, Dajun Yang, Peter P Roller

Journal:

Biochemical and Biophysical Research Communications

Year:

2003

Language:

english

File:

PDF, 298 KB

english, 2003

11

Conformationally Constrained Analogues of Diacylglycerol. 26. Exploring the Chemical Space Surrounding the C1 Domain of Protein Kinase C with DAG-Lactones Containing Aryl Groups at the sn -1 and sn -2 Positions

Kang, Ji-Hye, Benzaria, Samira, Sigano, Dina M., Lewin, Nancy E., Pu, Yongmei, Peach, Megan L., Blumberg, Peter M., Marquez, Victor E.

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 358 KB

english, 2006

12

Conformational energy range of ligands in protein crystal structures: The difficult quest for accurate understanding

Peach, Megan L., Cachau, Raul E., Nicklaus, Marc C.

Journal:

Journal of Molecular Recognition

Year:

2017

Language:

english

File:

PDF, 612 KB

english, 2017

13

PDB Ligand Conformational Energies Calculated Quantum-Mechanically

Sitzmann, Markus, Weidlich, Iwona E., Filippov, Igor V., Liao, Chenzhong, Peach, Megan L., Ihlenfeldt, Wolf-Dietrich, Karki, Rajeshri G., Borodina, Yulia V., Cachau, Raul E., Nicklaus, Marc C.

Journal:

Journal of Chemical Information and Modeling

Year:

2012

Language:

english

File:

PDF, 3.42 MB

english, 2012

14

Conformationally Constrained Analogues of Diacylglycerol (DAG). 28. DAG-dioxolanones Reveal a New Additional Interaction Site in the C1b Domain of PKCδ

Choi, Yongseok, Pu, Yongmei, Peach, Megan L., Kang, Ji-Hye, Lewin, Nancy E., Sigano, Dina M., Garfield, Susan H., Blumberg, Peter M., Marquez, Victor E.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 814 KB

english, 2007

15

Synthetic derivatives of the SUMO consensus sequence provide a basis for improved substrate recognition

Leyva, Melissa J., Kim, Yeong Sang, Peach, Megan L., Schneekloth, John S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.27 MB

english, 2015

16

Diacylglycerol Lactones Targeting the Structural Features That Distinguish the Atypical C1 Domains of Protein Kinase C ζ and ι from Typical C1 Domains

Pu, Yongmei, Kang, Ji-Hye, Sigano, Dina M., Peach, Megan L., Lewin, Nancy E., Marquez, Victor E., Blumberg, Peter M.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.76 MB

english, 2014

17

Experimental and chemoinformatics study of tautomerism in a database of commercially available screening samples

Guasch, Laura, Yapamudiyansel, Waruna, Peach, Megan L., Kelley, James A., Barchi, Joseph J., Nicklaus, Marc C.

Journal:

Journal of Chemical Information and Modeling

Year:

2016

Language:

english

File:

PDF, 1.73 MB

english, 2016

18

Potent Grb2–SH2 domain antagonists not relying on phosphotyrosine mimics

Peng Li, Manchao Zhang, Ya-Qiu Long, Megan L. Peach, Hongpeng Liu, Dajun Yang, Marc Nicklaus, Peter P. Roller

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 261 KB

english, 2003

19

Epigenetic re-wiring of breast cancer by pharmacological targeting of C-terminal binding protein

Byun, Jung S., Park, Samson, Yi, Dae Ik, Shin, Jee-Hye, Hernandez, Sara Gil, Hewitt, Stephen M., Nicklaus, Marc C., Peach, Megan L., Guasch, Laura, Tang, Binwu, Wakefield, Lalage M., Yan, Tingfen, Cab

Journal:

Cell Death and Disease

Year:

2019

Language:

english

File:

PDF, 1.77 MB

english, 2019

20

Alcohol and other substance use among a sample of young people in the Solomon Islands

Quinn, Brendan, Peach, Elizabeth, Wright, Cassandra J.C., Lim, Megan S.C., Davidson, Lisa, Dietze, Paul

Journal:

Australian and New Zealand Journal of Public Health

Year:

2017

Language:

english

File:

PDF, 122 KB

english, 2017

21

α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine Releasing Protein 3 (RasGRP3) Ligands

Ann, Jihyae, Czikora, Agnes, Saini, Amandeep, Zhou, Xiaoling, Mitchell, Gary A., Lewin, Nancy E., Peach, Megan L, Blumberg, Peter M., Lee, Jeewoo

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 953 KB

english, 2018

22

Combining docking with pharmacophore filtering for improved virtual screening

Megan L Peach, Marc C Nicklaus

Journal:

Journal of Cheminformatics

Year:

2009

Language:

english

File:

PDF, 1.59 MB

english, 2009

23

Structure-based design of potent Grb2–SH2 domain antagonists not relying on phosphotyrosine mimics

Sheng Jiang, Peng Li, Megan L. Peach, Lakshman Bindu, Karen W. Worthy, Robert J. Fisher, Terrence R. Burke Jr., Marc Nicklaus, Peter P. Roller

Journal:

Biochemical and Biophysical Research Communications

Year:

2006

Language:

english

File:

PDF, 234 KB

english, 2006

24

Computational tools and resources for metabolism-related property predictions. 1. Overview of publicly available (free and commercial) databases and software

Peach, Megan L, Zakharov, Alexey V, Liu, Ruifeng, Pugliese, Angelo, Tawa, Gregory, Wallqvist, Anders, Nicklaus, Marc C

Journal:

Future Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.52 MB

english, 2012

25

Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies

Sterner, Eric, Peach, Megan L., Nicklaus, Marc C., Gildersleeve, Jeffrey C.

Journal:

Year:

2017

Language:

english

File:

PDF, 2.72 MB

english, 2017

26

Molecular Modeling, Total Synthesis, and Biological Evaluations of C9-Deoxy Bryostatin 1

Gary E. Keck, Yam B. Poudel, Arnab Rudra, Jeffrey C. Stephens, Noemi Kedei, Nancy E. Lewin, Megan L. Peach, Peter M. Blumberg

Journal:

Angewandte Chemie International Edition

Year:

2010

Language:

english

File:

PDF, 540 KB

english, 2010

27

Discovery of a Novel Nonphosphorylated Pentapeptide Motif Displaying High Affinity for Grb2-SH2 Domain by the Utilization of 3‘-Substituted Tyrosine Derivatives

Song, Yan-Li, Peach, Megan L., Roller, Peter P., Qiu, Su, Wang, Shaomeng, Long, Ya-Qiu

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 405 KB

english, 2006

28

A New Approach to Radial Basis Function Approximation and Its Application to QSAR

Zakharov, Alexey V., Peach, Megan L., Sitzmann, Markus, Nicklaus, Marc C.

Journal:

Journal of Chemical Information and Modeling

Year:

2014

Language:

english

File:

PDF, 592 KB

english, 2014

29

Computer-assisted search and optimization of new human immunodeficiency virus integrase inhibitors

D. S. Druzhilovsky, D. A. Filimonov, Chenzhong Liao, Megan Peach, Mark Nicklaus, V. V. Poroikov

Journal:

Biochemistry (Moscow) Supplemental Series B: Biomedical Chemistry

Year:

2010

Language:

english

File:

PDF, 206 KB

english, 2010

30

Structural basis for the failure of the C1 domain of RasGRP2 to bind phorbol ester with high affinity

Czikora, Agnes, Lundberg, Daniel J., Abramovitz, Adelle, Lewin, Nancy E., Kedei, Noemi, Peach, Megan L., Zhou, Xiaoling, Merritt, Raymond C., Craft, Elizabeth A., Braun, Derek C., Blumberg, Peter M.

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 1.88 MB

english, 2016

31

Risk of death among people with rare autoimmune diseases compared to the general population in England during the 2020 COVID-19 pandemic

Peach, Emily, Rutter, Megan, Lanyon, Peter, Grainge, Matthew J, Hubbard, Richard, Aston, Jeanette, Bythell, Mary, Stevens, Sarah, Pearce, Fiona

Journal:

Year:

2020

File:

PDF, 490 KB

2020

32

Computational tools and resources for metabolism-related property predictions. 2. Application to prediction of half-life time in human liver microsomes

Zakharov, Alexey V, Peach, Megan L, Sitzmann, Markus, Filippov, Igor V, McCartney, Heather J, Smith, Layton H, Pugliese, Angelo, Nicklaus, Marc C

Journal:

Future Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 939 KB

english, 2012

33

Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP

Garcia, Lia C., Donadío, Lucia Gandolfi, Mann, Ella, Kolusheva, Sofiya, Kedei, Noemi, Lewin, Nancy E., Hill, Colin S., Kelsey, Jessica S., Yang, Jing, Esch, Timothy E., Santos, Marina, Peach, Megan L.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.14 MB

english, 2014

34

Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP

Elhalem, Eleonora, Donadío, Lucía Gandolfi, Zhou, Xiaoling, Lewin, Nancy E., Garcia, Lia C., Lai, Christopher C., Kelley, James A., Peach, Megan L., Blumberg, Peter M., Comin, María J.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.15 MB

english, 2017

35

Directed Discovery of Agents Targeting the Met Tyrosine Kinase Domain by Virtual Screening

Peach, Megan L., Tan, Nelly, Choyke, Sarah J., Giubellino, Alessio, Athauda, Gagani, Burke, Terrence R., Nicklaus, Marc C., Bottaro, Donald P.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.64 MB

english, 2009

36

Small nonphosphorylated Grb2–SH2 domain antagonists evaluated by surface plasmon resonance technology

Feng-Di T. Lung, Chiung-Wen Chang, Meng-Chin Chong, Chien-Chung Liou, Peng Li, Megan L. Peach, Marc C. Nicklaus, Bih-Show Lou, Peter P. Roller

Journal:

Year:

2005

Language:

english

File:

PDF, 149 KB

english, 2005

37

ChemInform Abstract: Isolation, Structural Elucidation, and Absolute Stereochemistry of Enigmazole A, a Cytotoxic Phosphomacrolide from the Papua New Guinea Marine Sponge Cinachyrella enigmatica.

Naoya Oku, Kentaro Takada, Richard W. Fuller, Jennifer A. Wilson, Megan L. Peach, Lewis K. Pannell, James B. McMahon, Kirk R. Gustafson

Journal:

Year:

2010

File:

PDF, 23 KB

2010

38

Modeling the transmembrane domain of bacterial chemoreceptors

Megan L. Peach, Gerald L. Hazelbauer, Terry P. Lybrand

Journal:

Protein Science

Year:

2002

Language:

english

File:

PDF, 3.66 MB

english, 2002

39

Synthesis of seco -B-Ring Bryostatin Analogue WN-1 via C–C Bond-Forming Hydrogenation: Critical Contribution of the B-Ring in Determining Bryostatin-like and Phorbol 12-Myristate 13-Acetate-like Properties

Andrews, Ian P., Ketcham, John M., Blumberg, Peter M., Kedei, Noemi, Lewin, Nancy E., Peach, Megan L., Krische, Michael J.

Journal:

Journal of the American Chemical Society

Year:

2014

Language:

english

File:

PDF, 1.93 MB

english, 2014

40

Tricyclic Guanidine Alkaloids from the Marine Sponge Acanthella cavernosa that Stabilize the Tumor Suppressor PDCD4

Grkovic, Tanja, Blees, Johanna, Bayer, Magdalena, Colburn, Nancy, Thomas, Cheryl, Henrich, Curtis, Peach, Megan, McMahon, James, Schmid, Tobias, Gustafson, Kirk

Journal:

Year:

2014

Language:

english

File:

PDF, 589 KB

english, 2014

41

SAVI, in silico generation of billions of easily synthesizable compounds through expert-system type rules

Patel, Hitesh, Ihlenfeldt, Wolf-Dietrich, Judson, Philip N., Moroz, Yurii S., Pevzner, Yuri, Peach, Megan L., DelannÃ©e, Victorien, Tarasova, Nadya I., Nicklaus, Marc C.

Journal:

Scientific Data

Year:

2020

File:

PDF, 2.57 MB

2020

42

Isolation, Structural Elucidation, and Absolute Stereochemistry of Enigmazole A, a Cytotoxic Phosphomacrolide from the Papua New Guinea Marine Sponge Cinachyrella enigmatica

Oku, Naoya, Takada, Kentaro, Fuller, Richard W., Wilson, Jennifer A., Peach, Megan L., Pannell, Lewis K., McMahon, James B., Gustafson, Kirk R.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 679 KB

english, 2010

43

Conformationally Constrained Analogues of Diacylglycerol (DAG). 25. Exploration of the sn -1 and sn -2 Carbonyl Functionality Reveals the Essential Role of the sn -1 Carbonyl at the Lipid Interface in the Binding of DAG-Lactones to Protein Kinase C

Kang, Ji-Hye, Peach, Megan L., Pu, Yongmei, Lewin, Nancy E., Nicklaus, Marc C., Blumberg, Peter M., Marquez, Victor E.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 283 KB

english, 2005

44

Macrophilone A: Structure Elucidation, Total Synthesis, and Functional Evaluation of a Biologically Active Iminoquinone from the Marine Hydroid Macrorhynchia philippina

Zlotkowski, Katherine, Hewitt, William M., Yan, Pengcheng, Bokesch, Heidi R., Peach, Megan L., Nicklaus, Marc C., O’Keefe, Barry R., McMahon, James B., Gustafson, Kirk R., Schneekloth, John S.

Journal:

Organic Letters

Year:

2017

Language:

english

File:

PDF, 1.25 MB

english, 2017

45

Synthesis of a des -B-Ring Bryostatin Analogue Leads to an Unexpected Ring Expansion of the Bryolactone Core

Kraft, Matthew B., Poudel, Yam B., Kedei, Noemi, Lewin, Nancy E., Peach, Megan L., Blumberg, Peter M., Keck, Gary E.

Journal:

Journal of the American Chemical Society

Year:

2014

Language:

english

File:

PDF, 1.47 MB

english, 2014

46

Tautomerism of Warfarin: Combined Chemoinformatics, Quantum Chemical, and NMR Investigation

Guasch, Laura, Peach, Megan L., Nicklaus, Marc C.

Journal:

Journal of Organic Chemistry

Year:

2015

Language:

english

File:

PDF, 2.59 MB

english, 2015

47

Differential Binding Modes of Diacylglycerol (DAG) and DAG Lactones to Protein Kinase C (PK-C)

Sigano, Dina M., Peach, Megan L., Nacro, Kassoum, Choi, Yongseok, Lewin, Nancy E., Nicklaus, Marc C., Blumberg, Peter M., Marquez, Victor E.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 420 KB

english, 2003

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